The Tucson, Arizona, native emerged with the lead under the final 100 laps following a stellar service from his pit crew to tame his first Monster Mile victory.
The 2012 Cup champion overtook Matt DiBenedetto on the final lap and held off the field to claim his first Cup victory of the 2021 season at the world's fastest venues.
The two-time Xfinity Series champion from Olive Branch, Mississippi, is set to achieve a major milestone start in the Cup circuit at the paper clip-shaped track.
The 2018 Cup champion stormed to the front in the late stages and outlasted the field in overtime to win the inaugural Cup event on the Bristol Dirt Course.
With new names on the grid, new stakes on the line and a new start on the horizon for all teams, the 2021 FIA Formula One World Championship season is hours away from commencing.