The two-time Cup champion from Las Vegas, Nevada, benefitted from a final lap collision involving Tyler Reddick and Chase Briscoe to become the ninth different competitor to reach 60 victories in NASCAR's premier series.
The 24-year-old Byron from Charlotte, North Carolina, led a race-high 212 of 403 and fended off Joey Logano during an overtime shootout to repeat as a Cup winner at the Paperclip-shaped short track.
The three-time Daytona 500 champion from Chesterfield, Virginia, fended off Kevin Harvick in the final five laps to notch a breakthrough victory at his home track.
The Mitchell, Indiana, native became the 200th different competitor to achieve a win in NASCAR's premier series following his first career victory in the desert state.