The Tampa, Florida, native erased his difficult regular-season stretch by guaranteeing himself a 2021 Cup Playoff berth following a late victory in the Magic Mile.
The reigning seven-time F1 champion recorded a controversial victory at Silverstone Circuit following an early incident with title rival Max Verstappen.
The 26-year-old Ferguson from Lincolnton, North Carolina, will make his second career Truck start with Kaulig Racing more than a month after making his Truck debut at Bristol.
Spire Motorsports has earned one win and three top five finishes. Rajah Caruth took the checkered flag in last year's Rackley Roofing 200 after leading 61 laps.
In 12 previous NASCAR Cup Series starts at Nashville (Tenn.) Superspeedway, Spire Motorsports has two top-five finishes with a best result of second earned twice by Zane Smith (2024) and Carson Hocevar (2025).