The Welcome, North Carolina, native utilized a crossover move to overtake Wallace on the final lap and claim the victory in the second Daytona Duel event.
The two-time Cup champion benefitted from a last lap incident involving Chase Elliott and Ryan Blaney to steal the win in the first Busch Clash event on Daytona's RC.
The 2021 Busch Clash at the Daytona International Speedway Road Course will have Ryan Blaney and his No. 12 Team Penske Ford Mustang start on pole position following a random draw and with a new season of NASCAR competition hours away from commencing.
The 26-year-old Ferguson from Lincolnton, North Carolina, will make his second career Truck start with Kaulig Racing more than a month after making his Truck debut at Bristol.
Spire Motorsports has earned one win and three top five finishes. Rajah Caruth took the checkered flag in last year's Rackley Roofing 200 after leading 61 laps.
In 12 previous NASCAR Cup Series starts at Nashville (Tenn.) Superspeedway, Spire Motorsports has two top-five finishes with a best result of second earned twice by Zane Smith (2024) and Carson Hocevar (2025).