Cindric, a four-time Xfinity Series race winner of 2020, will lead the field to the start of the inaugural Daytona RC event in NASCAR's new competition-based formula.
Six spots remain vacant and two competitors each trail the Playoff cutline by 26 points following an eventful Cup doubleheader weekend at the Irish Hills.
The 35-year-old Preece from Berlin, Connecticut, led 46 of 200 laps and outlasted sleet conditions and numerous on-track chaos to become the 27th competitor to win the Clash.
Josh Berry won the Last Chance Qualifier race while Austin Cindric outbattled Corey LaJoie for the second spot after a spirited side-by-side battle over the closing laps. Berry and Cindric will compete in the Clash Main Event at Bowman Gray Stadium
Joe Gibbs Racing driver Denny Hamlin was made available to the media on Wednesday prior to practice for the NASCAR Cup Series Clash at Bowman Gray Stadium.